PT-141 – Information

PT-141 Bremelanotide in the form of injection is FDA-approved to treat HSDD in women, but the peptide's affect was originally discovered in men. While researching a drug to darken skin, researchers noticed that men got spontaneous erections.

Studies on intranasal administration of PT-141 reported the spray has the same impact as the injection.

An article published in The Journal Nature on the effect of PT-141 nasal spray in with ED and men without ED, showed the effects of PT-141 nasal were "clinically significant". Both study groups achieved erections when using the PT-141.

 

What Is PT-141?

 

PT-141 is an agonist at melanocortin receptors. This means it activates the receptors, causing a response. Melanocortin receptors control sexual function, impact appetite, and immunity, among other physiologic actions.

PT-141 offers promise treating sexual dysfunction in men and women who do not have success with the PDE5 inhibitors Viagra (sildenafil) and Cialis (tadalafil) or can't take sildenafil or tadalafil for health reasons.

 

How PT-141 Works

 

PT-141 is a peptide drug that affects neurotransmitters in the brain called melanocortins. It is not known exactly how PT-141 can cause erections in men and increase women's libido and sexual satisfaction.

 

What Is the Difference Between PT-141 And Cialis And Viagra?

 

PT-141's main works in the brain, while Cialis (tadalafil) and Viagra (sildenafil) essentially impact blood vessels.

 

How Do PDE5 Inhibitors Work?

 

Inhibiting, or blocking, the enzyme phosphodiesterase 5 (PDE5), slows the breakdown of the molecule cGMP. With cGMP still active, the smooth muscles in the penis relax or stay relaxed longer. When the muscles relax, blood vessels open to increase blood flow. This is called vasodilation.

 

Studies show PDE5 inhibitors may have the same effect in premenopausal and postmenopausal women. 

They increase blood flow to the vagina and clitoris, which boosts libido, increases vaginal lubrication and improves sexual satisfaction.

 

Again, not all men and women experience success with PDE5 inhibitors. The same is true for PT-141.

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